Pathogenic variants in <i>BRAT1</i> are associated with a spectrum of clinical syndromes ranging from Lethal Neonatal Rigidity and Multifocal Seizure syndrome (RMFSL) to Neurodevelopmental Disorder with Cerebellar Atrophy and with or without Seizures (NEDCAS). The gene discussed is BRAT1; the disease is neurodevelopmental disorder.