While other stimuli, such as bacterial lipopolysaccharide (LPS), simulate infection-associated defense mechanisms and trigger microglia-mediated neurotoxicity (Chien et al., 2016), IFNγ is a sterile stimulus actively involved in AD pathology, with a neuroimmune role over microglia activation and synaptic activity (Ta et al., 2019). Here, IFNG is linked to Alzheimer disease.