APP and Alzheimer disease: PAWR (aliased as PAR-4) is a tumor suppressor protein linked to NF-κB and BCL2 direct inhibition (Chakraborty et al., 2001; Yang et al., 2016), also indicated as an AD biomarker involved in the regulation of BACE1-mediated APP processing (Xie and Guo, 2005; Greco et al., 2012).