NFE2L2 and Schnyder corneal dystrophy: Therefore, we used SS mice to show that prophylactic pharmacologic activation of Nrf2 with 3H-1,2 Dithiole-3-thione (D3T) during the adolescent-to-adult transition was efficacious to stabilize hemoglobin loss, ameliorate lung injury and reverse vascular inflammation with aging in SCD (Ghosh et al., 2016).