NFE2L2 and endothelial dysfunction: We also reported that loss of Nrf2 in non-hematopoietic tissue was found to impact disease progression in non-hematopoietic tissues such as the vasculature, leading to endothelial dysfunction with aging in SS mice; most notably, loss of Nrf2 in non-hematopoietic tissue also worsened intravascular hemolysis with aging (Ghosh et al., 2016).