Note, the genes that we hypothesized would be the most clinically relevant for SCD patients are heme-oxygenase (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), glutamate cysteine ligase modifier subunit (GCLM) and glutamate cysteine ligase catalytic subunit (GCLC). This evidence concerns the gene GCLC and Schnyder corneal dystrophy.