HMOX1 and non-small cell lung carcinoma: Li et al. showed that the expression of HO-1 was significantly increased by knockdown of endogenous miR-1304 by CRISPR/Cas9, and miR-1304 inhibited NSCLC cell growth by targeting HO-1, demonstrating that modulation of miR-1304/HO-1 may be a novel therapeutic avenue (Li et al., 2017).