Yu et al. knocked down Aurora-B in the A549 cell line by CRISPR/Cas9 technology, and demonstrated that Aurora-B could confer NSCLC drug resistance by inhibiting cell proliferation, p53 related DNA damage response and apoptotic pathways, while knocking down Aurora-B was able to restore cell sensitivity to cisplatin and paclitaxel (Yu et al., 2018). Here, AURKB is linked to non-small cell lung carcinoma.