EGFR and non-small cell lung carcinoma: Zeng et al., through genome-wide CRISPR/Cas9 gene screening, found that inactivation of GPCR related effectors produced obvious synergistic effects with EGFR inhibition in EGFR mutated NSCLC cells, deficiency of GPCR related effector - RIC8A could improve cell sensitivity to chemotherapeutic drugs, and targeting RIC8A is promising as a new approach to preventing EGFR-TKI resistance in NSCLC (Zeng et al., 2019).