Lee et al. used CRISPR/Cas9 libraries to screen human lung cancer cell lines (NCI-H820) and knockdown of the genes MDM4, PSMA6, PSMB6, ANAPC5, and CDK1 increased the sensitivity of lung cancer cells to the EGFR-TKI Erlotinib, the MDM4 inhibitor nutlin-3 synergized with PSMA6, and the PSMB6 inhibitor Carfilzomib synergized with Erlotinib in vitro cell lines and in vivo patient-derived xenograft experiments, can promote tumor cell death, target cell cycle or protein ubiquitination pathways, and may inhibit Erlotinib resistance progression (Lee et al., 2021). Here, MDM4 is linked to neoplasm.