Rakshit et al. used CRISPR/Cas9 to knock down BRCA1 in human CD4 + T helper cells and demonstrated that the expression of the BRCA1 gene in the VEGFA and aimp1 loci was suppressed in NSCLC, and aberrant expression of multiple DNA damage/repair factors was found in the aimp1 and VEGFA loci. The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.