Raoof et al. identified FGFR1 as the highest genomic target to re-sensitize cells to EGF816 using a genome-wide CRISPR screen, and EGFR inhibitors synergize with FGFR1 inhibitors to overcome chemoresistance in NSCLC with mesenchymal features (Raoof et al., 2019). This evidence concerns the gene EGFR and non-small cell lung carcinoma.