C-MET proto-oncogene, receptor tyrosine kinase (c-MET), a transmembrane receptor encoded by the met gene, belongs to the hepatocyte growth factor (HGF) receptor family, and HGF, in combination with c-MET, undergoes phosphorylation and autophosphorylation and activates downstream PI3 K/Akt and MAPK signaling pathways (Pasquini and Giaccone, 2018), MET amplification accounts for 5%–20% of NSCLC patients and is a poor prognostic factor for EGFR-TKI acquired resistance (Bubendorf et al., 2017). This evidence concerns the gene EGFR and non-small cell lung carcinoma.