Our experimental results showed that the expression of IL6, Stat3, and HIF-1α increased significantly in the asthma model group, and the sperm concentration and total sperm viability decreased significantly in the model group, which proved that asthma could increase the expression of IL6, Stat3, and HIF-1α protein, promote the apoptosis of spermatogenic cells, and lead to infertility. Here, HIF1A is linked to Infertility.