S100B is increased in the pro-inflammatory context of multiplesclerosis.4,5,9 Based on our previous findings9 and to explore theimportance of S100B in multiple sclerosis development, we used the EAE model,which mimics the inflammation and demyelination of the CNS.17 For this, homozygotic(S100B WT) and KO (S100B KO) mice were obtained. The gene discussed is S100B; the disease is multiple sclerosis.