Additional confirmation for IL-17A involvement in SS comes from observations in the Ro52-null mice that develop SS-like manifestations comprising dermatitis, autoantibody formation, hypergammaglobulinemia, lymphadenopathy, splenomegaly, and kidney pathology characterized by proteinuria with mesangium and intraglomerular immunoglobulin depositions [100]. Here, IL17A is linked to synovial sarcoma.