Mice lacking Regnase-1 display a phenotype of autoimmunity that resembles systemic lupus erythematosus (SLE) in humans, including antinuclear antibodies, anti-double-stranded DNA (dsDNA), autoantibodies, hyperglobulinemia, anemia, plasma cell infiltration in lung interstitial tissue, and splenomegaly and lymphadenopathy [42]. Here, ZC3H12A is linked to systemic lupus erythematosus.