TRAF3IP2 and Lymphadenopathy: Thus, Act1 knockout mice develop lymphadenopathy and splenomegaly, hypergammaglobulinemia, and autoantibody formation, where Act1-deficient B cells exhibit stronger IkappaB (IkB) phosphorylation, NFkB2 signaling, and activation of JNK, ERK, and p38 pathways [37].