Additionally, elevated CRP levels should be considered one more parameter in the overall assessment of T2DM risk, besides elevated FPG and HbA1C levels, abnormal OGTT, hyperinsulinemia, etc. Thus, elevated CRP levels in patients with higher T2DM risk must warn the clinician to perform available diagnostic procedures to confirm diabetes [194, 195]. This evidence concerns the gene CRP and Hyperinsulinemia.