Similarly, RNAi inhibition of the P. aeruginosa-up-regulated ncr-1 and C27B7.7 (DSCAM) led to increased host sensitivity to infection, implicating both genes in the worm immune response to P. aeruginosa gut infections, while RNAi inhibition of ncr-1 (only gene found up-regulated in this context) did not sensitize worms to S. aureus infection. This evidence concerns the gene NCR1 and infection.