Amongst the 73 DE genes common to all three pathogen infections, only ncr-1 [homolog of the vertebrate gene Niemann-Pick disease, type C1 (NPC1)], a sterol-sensing domain-containing protein involved in cholesterol trafficking (Patel et al., 2008) can be associated with HHLS (Figure 3B), as most gene expression changes in the HHLS pathway seem pathogen-specific. This evidence concerns the gene NPC1 and Pick disease.