Concerning the targeting NF-κB with respect to its activity in the different cellular compartments, we demonstrated that targeting or silencing IκBα with PSA in the IκBα-overespressing lung cancer cells, significantly induce mitochondria OXPHOS and increased ROS content and release, correlating with a significant increased sensitivity to apoptotic cell death (Carra et al., 2021). Here, NFKBIA is linked to lung cancer.