FEN1 was reported to elevate the expression of DNMT3A and promote their interaction among FEN1/PCNA/DNMT3A and suppressed the expression of miR-200a-5p, leading to upregulation of miR-200a-5p targets, MET and EGFR, which contribute to enhancement of growth of breast cancer cells (Zeng et al., 2019). This evidence concerns the gene EGFR and breast cancer.