CDH1 and breast cancer: Furthermore, one study determined a molecular mechanism by which DNMT3b7 (aberrant DNMT3b transcripts) promotes tumor progression in breast cancer cells through hypermethylation and loss of CDH1/E-cadherin expression, altered β-catenin localization, and subsequent changes in cell adhesion, proliferation, and growth in soft agar (Brambert et al., 2015).