Moreover, miR-200b, miR-200c and miR-221 target DNMT3B expression, while DNMT3B can also stimulate the DNA methylation of miR-200s in CAFs and further indicated that TGF-β1/miR-200s/miR-221/DNMT3B axis governed CAF status to stimulate proliferation of breast cancer cells (Tang et al., 2019). The gene discussed is DNMT3B; the disease is breast carcinoma.