It is found that TRPV1 mRNA expression level was associated with the poor prognostic potential of LUAD patient cohorts in most of these factors we discussed above (Tables S2 and S3). This striking phenomenon is that the divergent OS patterns of LUAD and LUSC may refer to the correlation between TRPV1 and the prognosis of various types of cancer, depending on the diverse mechanisms of tumor initiation and progression. This evidence concerns the gene TRPV1 and neoplasm.