IRF5 and neoplasm: These data showed that the marker genes’ mRNA expression levels in T‐cells (CD8+, effector T, resident memory T, naive T), monocyte, tumor‐associated macrophage, M1 macrophages, natural killer cell, and DCs were negatively correlated to the TRPV1 mRNA expression level in LUAD cohorts (Table S4, Figure S2). Furthermore, we found that NOS2, PTGS2, and IRF5 of M1 phenotype are nonsignificantly correlated with TRPV1 mRNA level in LUAD, while IRF5 is significantly positive with TRPV1 expression (Table S4).