The top 10 most deregulated pathways (i.e. with the highest median PDS z-score) were steroid hormone biosynthesis, focal adhesion, 2-oxocarboxylic acid metabolism, fatty acid degradation, Rap1 signalling pathway, peroxisome proliferator-activated receptor (PPAR) signalling pathway, morphine addiction, retrograde endocannabinoid signalling, amyotrophic lateral sclerosis (ALS) pathway and arrhythmogenic right ventricular cardiomyopathy (ARVC). This evidence concerns the gene PPARA and Arrhythmogenic right ventricular dysplasia.