Indeed, five different TMRs regulate ALS genes (AR, ELF5, HOXA2, nuclear receptor subfamily 0 group B member 1 (NR0B1) and NR5A2), several of which have been related to different types of cancer (C9orf72, multiple cancers; DERL1, non-small-cell lung cancer, bladder cancer, colon cancer, breast carcinoma; DNAH9, gastric adenocarcinoma; DCTN4, colon adenocarcinoma; COX4I1, skin cancer; UQCRC2, gastric cancer, glioma, testicular cancer, colorectal cancer, hepatocarcinoma; PPP3CA, ovarian cancer) [95,116–130]. The gene discussed is COX4I1; the disease is skin neoplasm.