The top 10 most deregulated pathways (i.e. with the highest median PDS z-score) were steroid hormone biosynthesis, focal adhesion, 2-oxocarboxylic acid metabolism, fatty acid degradation, Rap1 signalling pathway, peroxisome proliferator-activated receptor (PPAR) signalling pathway, morphine addiction, retrograde endocannabinoid signalling, amyotrophic lateral sclerosis (ALS) pathway and arrhythmogenic right ventricular cardiomyopathy (ARVC). The gene discussed is PPARA; the disease is arrhythmogenic right ventricular cardiomyopathy.