In the present study, we identified thirteen immune hub genes (CD86, HSPA4, FOS, GRB2, KRAS, PTPN11, PTPRC, TLR2, PIK3R1, IGF1, JUN, HSP90AA1, and STAT3) associated with Braak stages in AD through WGCNA and the cytoHubba plugin. This evidence concerns the gene FOS and Alzheimer disease.