In the present study, we identified thirteen immune hub genes (CD86, HSPA4, FOS, GRB2, KRAS, PTPN11, PTPRC, TLR2, PIK3R1, IGF1, JUN, HSP90AA1, and STAT3) associated with Braak stages in AD through WGCNA and the cytoHubba plugin. The gene discussed is TLR2; the disease is Alzheimer disease.