Among the newly included renal cell tumors in the 2016 WHO classification were some entities with specific molecular alterations such as fumarate hydratase (FH)-deficient RCC, succinate dehydrogenase (SDH)-deficient renal carcinoma and others such as tubulocystic RCC, clear cell papillary RCC and acquired cyctic disease-associated RCC (12, 13). This evidence concerns the gene FH and renal carcinoma.