We then divided the 1339 genes in the blue module into two groups based on the TNM stage (stage I/II 332; III/IV 267) in the TCGA database and obtained 312 genes differentially expressed in stage I/II and stage III/IV (SET1), which may play vital roles in CRC metastasis (Figure 2E). The gene discussed is SETD1A; the disease is colorectal carcinoma.