Hence, to evaluate the potential of AQP5 as a novel diagnostic and prognostic marker of pancreatic cancer, we explored the whole genome expression data of patients with PAAD from Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), UALCAN, and Gene Expression Profiling Interactive Analysis (GEPIA) databases. This evidence concerns the gene AQP5 and pancreatic adenocarcinoma.