KEGG pathway analysis showed that the co-expressed genes were enriched in renal cell carcinoma, ErbB signaling pathway, Shigellosis protein processing in the endoplasmic reticulum, neurotrophin signaling pathway, and ubiquitin-mediated proteolysis pathways in cancer in PAAD (Figure 7H). The gene discussed is BDNF; the disease is hereditary clear cell renal cell carcinoma.