Univariate Cox regression analysis indicated that pathologic stage II (HR = 2.333, p = 0.033), histologic G3 (HR = 2.625, p = 0.007), and AQP5 (HR = 1.142, p = 0.009) were factors that affected the survival of patients with PAAD. Here, AQP5 is linked to pancreatic adenocarcinoma.