TP53AIP1 inhibits proliferation and growth of breast cancer cells through cell-cycle arrest, apoptosis induction, elevation of the expression of cleaved-caspase-3, cleaved-caspase-9, Bax, p53, and the inhibition of Bcl-2, Ki67, and PI3K/Akt pathways (35). Here, CASP3 is linked to breast carcinoma.