Patients in the low-eGFR group were significantly older, had a higher mean BMI, longer duration of T2DM, higher prevalence of hypertension and hypoglycemia compared with patients in the high-eGFR group; the low-eGFR group also had higher levels of BUN, SCr, uric acid, and UACR; a higher proportion of patients in the low-eGFR group were taking RAAS inhibitors and insulin. This evidence concerns the gene INS and Hypoglycemia.