GCH1 and colorectal carcinoma: Studies have shown that GCH1 and BH4 prevent cells from lipid peroxidation damage during ferroptosis induction (24).Rrecent study revealed that the decrease of GCH1 and BH4 levels can promotes erastin-induced ferroptosis in colorectal cancer (CRC) cells, and this may be related to the reduction of NRF2, which needs to be further provn (25).