We observed that at 8 days of pregnancy and 7 days of infection with P. berghei ANKA mice exhibited substantial embryo loss associated with high expression of HO-1 and hallmarks of ferroptotic cell death such as iron-induced lipid peroxidation, upregulation of Ptgs2 and downregulation of Gpx4. On the other hand, HO-1 inhibition induced the opposite effects, improving pregnancy outcome and highlighting the importance of HO-1 regulation for prevention of ferroptosis at implantation sites and maintenance of pregnancy during malaria in early pregnancy. Here, HMOX1 is linked to infection.