The interactions between DC-SIGN and CRC-specific glycosylation inhibit functional maturation and differentiation of Monocyte-Derived Dendritic Cells (MoDCs) and enhance anti-inflammatory cytokine secretions (e.g., IL-6 and IL-10), which might supply a tolerogenic microenvironment for CRC (137, 161). This evidence concerns the gene CD209 and colorectal carcinoma.