Although the role of Mincle in the relationship between intestinal fungal dysregulation and CRC is unclear, the ligands of Mincle hold great potential for the development of new cancer vaccine, such as promoting the lysis of mouse CRC cells (196) and enhancing the maturation and migration of DCs to trigger anti-tumor effect in CRC (197). The gene discussed is CLEC4E; the disease is colorectal carcinoma.