CEACAM5 and neoplasm: Malignant transformation alters the glycosylation process and causes increased levels of Lewis X and Lewis Y on tumor-specific CEA in intestinal epithelial cells(IECs), which can be selectively recognized by DC-SIGN to mediate the interaction between DCs and tumor cells, while normal IECs contains low levels of Lewis antigens on CEA thus avoiding DC-SIGN binding (139).