In addition to deteriorating experimental autoimmune encephalomyelitis (110) and systemic lupus erythematosus (111), Dectin-3 was initially found a limited role in regulating intestinal immunity (112), while later research revealed that Dectin-3 was also significant in intestinal homeostasis through interplaying with commensal fungi. The gene discussed is CLEC4D; the disease is systemic lupus erythematosus.