LGALS3 and gastroenteritis: Besides physically separating intestinal epithelia and the luminal microbiota or food to protect mucosa barrier, the dense mucus layer also prevents intestinal inflammation and enhances oral tolerance by mucin MUC2-mediated formation of galectin-3 (Gal-3) -Dectin-1-FcγRIIB complex, which inhibits NF-κB activation, downregulates pro-inflammatory cytokine and imprints DCs with anti-inflammatory characters (80).