In the liver, pathways were mostly enriched in metabolic pathways (Figure S3C) along with those associated with non-alcoholic liver disease (NAFLD), including retinol metabolism, peroxisome proliferator-activated receptor (PPAR), and forkhead box O (FoxO) signaling pathways (27) (Figure S3C). Here, PPARA is linked to metabolic dysfunction-associated steatotic liver disease.