iNKT cells can be induced by lipid and glycolipid antigens presented on the MHC Class I-related molecule CD1d, such as alpha-galactosylceramide (α-GalCer), to modulate experimental autoimmune encephalomyelitis (EAE) by secreting mixtures of cytokines typically associated with either pro-inflammatory [such as interferon gamma (IFN-γ)] or anti-inflammatory [such as interleukin 4 (IL-4)] responses (44). The gene discussed is CD1D; the disease is experimental autoimmune encephalomyelitis.