demonstrated that camp responsive element binding protein 1(CREB1) triggers long non-coding adjacent opposite strand RNA 1 (FOXD2-AS1), leading to increased cell proliferation and metastasis in gliomas via miR-185 sponging by targeting AKT Serine/Threonine Kinase 1(AKT1) (37). The gene discussed is CREB1; the disease is glioma.