CGAS and bacterial infectious disease: Martin and co-workers were the first to report STING mutant Drosophila had dysregulation of the IMD pathway, which resulted in reduced resistance by the intracellular bacterium Listeria monocytogenes. In this study, the authors demonstrated that CG7194, the closest homolog to cGAS in flies, did not cause any change in mortality against L. monocytogenes infection, suggesting that CG7194 (cGAS homolog) is not involved in activating STING signaling in bacterial infection and that signaling could be induced by the bacterial CDN 3′3′c-di-GMP.