To better understand the relationship between the phenotypic signatures that the in silico sorted TFH populations (Figure S1) take on specifically in HIV infection, we did pairwise comparisons of the distributions of CXCR3+, CXCR3-, and CXCR5- TFH populations within HIV+ donors across each cluster (Figure 1F). The gene discussed is CXCR5; the disease is HIV infectious disease.