As CD45RO+ T cells was not associated with EFS in the above analysis, we classified all NB patients into four groups according to the densities of CD3 and CD8, namely high densities of both CD3 and CD8 (CD3+CD8+), high density of CD3 but low density of CD8 (CD3+CD8-), low density of CD3 but high density of CD8 (CD3-CD8+) and low densities of both CD3 and CD8 (CD3-CD8-). Here, CD8A is linked to neuroblastoma.