ATG5 and asthma: Clinical studies showed that the autophagy marker LC3-II is highly expressed in neutrophils, T lymphocytes in sputum and neutrophils, and eosinophils and monocytes in the peripheral blood of patients with asthma, and the expression levels of autophagy pathway-related proteins Beclin-1, LC3B, and ATG5 are significantly increased in lung eosinophils compared with the control group (10–12).