FLCN and asthma: Significant DMPs fall within genes involved in the TFG-β related pathways (e.g. BMP2, FLCN, ING2, PMEPA1, PRDM16, TGFB1I1 and TGFBR3), in line with previous studies that reported an association between these genes and the increased asthma risk (63–68).