TP73 gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development; its role in airway epithelium is unknown, even if its homolog, TP63, is found to be essential for tracheobronchial epithelium development and homeostasis (70).Another interesting position with a lower methylation pattern in children with asthma was the cg05838113 located within the body of the ADAM8 gene, an ADAM Metallopeptidase Domain which is linked to asthma. This evidence concerns the gene TP73 and asthma.