The Rho family of GTPases has been proposed as a promising therapeutic target for asthma, and it is known to play an important role in the pathophysiology of asthma, including airway smooth muscle contraction, airway hyper‐responsiveness and bronchial epithelial barrier dysfunction and recently, in mesenchymal stem cell differentiation and migration for airway remodeling and repairing (69). Here, RHO is linked to asthma.