ADAM8 and asthma: TP73 gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development; its role in airway epithelium is unknown, even if its homolog, TP63, is found to be essential for tracheobronchial epithelium development and homeostasis (70).Another interesting position with a lower methylation pattern in children with asthma was the cg05838113 located within the body of the ADAM8 gene, an ADAM Metallopeptidase Domain which is linked to asthma.