Significant DMPs fall within genes involved in the TFG-β related pathways (e.g. BMP2, FLCN, ING2, PMEPA1, PRDM16, TGFB1I1 and TGFBR3), in line with previous studies that reported an association between these genes and the increased asthma risk (63–68). The gene discussed is PMEPA1; the disease is asthma.