reported that the levels of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1 beta (IL-1β) from monocytes/macrophage and interleukin 2 (IL-2), interferon-gamma (IFN-γ), and TNF-α from lymphocytes were much higher in patients with aldosteronoma than those in EH individuals, suggesting an active T-cell immunity in APA patients (38). This evidence concerns the gene IFNG and aldosterone-producing adenoma with seizures and neurological abnormalities.