Apoptosis signal‐regulating kinase 1 (ASK1) has been demonstrated to phosphorylate HDAC6 in response to oxygen changes, blocking the ubiquitination and subsequent proteasomal degradation of HDAC6, thus stabilizing this protein.[7] Since our work showed the critical involvement of the HDAC6‐cilium axis in the pathogenesis of ROP, we next explored whether targeting ASK1 could ameliorate the pathological changes associated with ROP. Here, MAP3K5 is linked to retinopathy of prematurity.