The identification of PDGFRA as the top receptor is highly consistent with current knowledge of GBM biology as knock‐down of PDGFRA leads to decreased invasion of GSCs.[57, 58, 59] Two of the most highly upregulated receptors (LGR6 and FPR1[60, 61, 62]) have been also implicated as drivers of invasion for other cancers, and three (FGFR4, LPR8, and F3) have little evidence of invasive properties in GBM or other cancers. This evidence concerns the gene LGR6 and glioblastoma.