For these studies, we chose to focus on two of the most significantly upregulated and novel ligand–receptor pairs: SAA1‐FPR1, because FPR1 expression increased with grade, and RSPO3‐LGR6, because LGR6 has also been noted to be involved in various types of cancers.[64, 65, 66, 67]. Here, SAA1 is linked to cancer.