RSPO3 and cancer: LGR6 has also been noted to be involved in various types of cancers, specifically ovarian cancer,[64] skin cancer,[65] gastric cancer,[66] and esophageal cancer.[67] Although, there has not been literature, to the best of our knowledge, that details the association of LGR6 with GBM, knockdown of LGR5 has been reported to suppress proliferation of glioma cells in vitro and in vivo.[95] LGR6 had significant upregulated expression in the triculture condition and its ligand RSPO3 was present in the triculture of astrocytes, ECs, and GB3‐RFPs, although most strongly in the ECs.