LGR6 and cancer: The identification of PDGFRA as the top receptor is highly consistent with current knowledge of GBM biology as knock‐down of PDGFRA leads to decreased invasion of GSCs.[57, 58, 59] Two of the most highly upregulated receptors (LGR6 and FPR1[60, 61, 62]) have been also implicated as drivers of invasion for other cancers, and three (FGFR4, LPR8, and F3) have little evidence of invasive properties in GBM or other cancers.