EIF2AK3 and ovarian carcinoma: To investigate the clinical relevance of the observed link between AZD1775 response, cellular senescence, and UPR activation, we performed bioinformatic analysis utilizing gene signatures (Table S1, Supporting Information) representing AZD1775 response, senescence, UPR, as well as PERK or XBP1s alone in multiple publicly available datasets of ovarian cancer.