Aberrant RLR activation leads to several types of autoimmune diseases, such as amyopathic dermatomyositis (ADM) [95], type 1 diabetes [96], SLE [97], Aicardi-Goutieres syndrome (AGS) [98], and Singleton-Merten syndrome (SMS) [99]. The gene discussed is DHX58; the disease is Aicardi-Goutieres syndrome.