As the most common form of dementia, Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease, featured by extracellular amyloid β plaques (Aβ) and intracellular tau neurofibrillary tangles of the brain which could have changed decades before the clinical stage and can be detected by biomarkers of positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) [1, 2]. This evidence concerns the gene MAPT and Alzheimer disease.