APOE and Alzheimer disease: Therefore, in this study, we aimed (1) to research the associations between LS7 and AD core hallmarks of CSF Aβ42, Aβ42/40, t-tau, and p-tau181 and the biomarker of CSF Aβ40 in cognitively intact adults and (2) to research the above relationship among different APOE ε4 allele statuses, age groups, and genders.