ANO4 and Hypoglycemia: In combination with whole-cell patch clamp and RNA-sequencing, we have identified that hypoglycemia activates GI-ERαvlVMH neurons through the opening of anoctamin 4 (Ano4, a chloride channel), and inhibits GE-ERαvlVMH neurons through the opening of the Abcc8-containing KATP channel [69].