CXCR4-transfected modified BMSCs were injected into a rat model of acute kidney injury (AKI) through the tail vein, and the results showed that the migration ability of the modified BMSCs was significantly increased after CXCR4 transfection, and the number of BMSCs homing into the rat AKI kidney tissue was found to be significantly increased. Here, CXCR4 is linked to acute kidney injury.