It has been suggested that TIMP3 modulates not only the action of MMPs but also other molecules, such as VEGF, EGF (epidermal growth factor), and TNF (tumor necrosis factor), and thus, it has a fundamental role in maintaining the homeostasis of RPE extracellular matrix and RPE metabolism in AMD progression [25]. The gene discussed is TIMP3; the disease is age-related macular degeneration.