As shown in the above data, overexpression of circLHFPL2 decreased activation of PI3K by upregulating PTEN, suggesting that circLHFPL2 may be a potential target that could overcome P-gp- and BCRP-mediated MDR of colon cancer with PIK3CA mutation. The gene discussed is ABCG2; the disease is malignant colon neoplasm.