Using univariant and multivariant Cox regression models, the results showed a significant difference in pulmonary disease (11.20, 95% CI 2.50–49.70, p = 0.001), age over 75 (3.92, 95% CI 1.61–9.73, p = 0.003), IgM (6.31, 95% CI 1.99–19.60, p = 0.002), CD16+/CD56+ NK cells (3.40, 95% CI 1.31–9.13, p = 0.014) and AST (4.60, 95% CI 1.31–16.00, p = 0.018) (Table 3), which were the 5 independent risk factors for progression from mild/moderate to severe disease (Fig. 1). Here, CD40LG is linked to lung disorder.