CRP and anemia (phenotype): The independent variables included pathogen type, elder (> 50 years old), bacterial infection, abnormal liver function (ALT > 37U/L), low PLT count (< 100 × 109/L), leukocytopenia (< 4.0 × 109/L), anemia (< 120 g/L), jaundice (total bilirubin > 20 μmol/L), high density infection (≥ 5% red blood cells infected), long DOF (> 5 days), misdiagnosis, hypoproteinemia (albumin < 35 g/L), PCT (procalcitonin), and CRP(C-reactive protein) were included in the full Cox model.