In July 2020, van der Made et al. [39] reported rare, deleterious germline variants in the TLR7. In this case series of four young men from two unrelated families with severe COVID-19, the identified variants were a maternally inherited 4-nucleotide deletion (c.2129_2132del; p.(Gln710Argfs*18)), and a missense variant (c.2383G>T; p.(Val795Phe)). The gene discussed is TLR7; the disease is COVID-19.