Furthermore, a more recent nested case–control study identified in the TLR7 gene, loss-of-function variants such as p.(Ser301Pro), p.(Arg920Lys) (rs189681811), and p.(Ala1032Thr) (rs147244662) found in 2.1% of young males with severe COVID-19 [40]. The gene discussed is TLR7; the disease is COVID-19.