Also, transcriptomic analysis of the CP in schizophrenia was shown to have an upregulation of immune and inflammation genes, which significantly correlated with disease status and greater levels of cortisol, resistin, C-reactive protein, tissue inhibitor of metalloproteinase 1, matrix metallopeptidase 9 (MMP-9), and pro-inflammatory markers in the serum and frontal cortex in the same individuals [95]. This evidence concerns the gene MMP9 and schizophrenia.