NES and Polydipsia: Next, based on the observation that 6–20% of individuals with schizophrenia display polydipsia (excessive drinking) [70–72], we measured daily water intake in Gdnf cHyper/cHyper;Nestin-Cre mice in individually housed male mice and female mice grouped housed in the IntelliCage setting, where the activity of each mouse is tracked with a subcutaneous transponder [73].