Further analysis at the cellular level revealed a reduced number of dopamine transporter-positive (DAT+) dopaminergic synaptic boutons in the medial PFC and in the association cortex in Gdnf cHyper/cHyper;Nestin-Cre mice compared with controls (Fig. 2D, E, Supplementary Fig. S2C, D), in line with reduced PFC dopaminergic innervation observed in post-mortem samples from individuals with schizophrenia [52]. The gene discussed is GDNF; the disease is schizophrenia.