To further elucidate the changes caused by increased endogenous GDNF levels that may contribute to phenotypes related to schizophrenia, we performed RNAseq in the striatum and substantia nigra (SN) of Gdnf cHyper;Nestin-Cre mice at 2–3 months of age and Gdnf cHyper mice 2 months after striatal AAV-Cre delivery (Supplementary Fig. S7A, C–J). Here, GDNF is linked to schizophrenia.