CBL and neoplasm: lncRNAs have been shown to regulate tumor immunity7,18 For example, Runqiu Jiang et al. found that lnc-EGFR binds to epidermal growth factor receptor (EGFR) specifically and blocks its interaction with and ubiquitination by c-CBL to induce EGFR expression and promote regulatory T cell (Treg) differentiation, thereby affecting the tumor immunosuppressive state19.