Our results also indicated that all the MED12m-positive and -negative uterine fibroids had DNA hypermethylation and increased mRNA expression in either SATB2 or NRG1, suggesting that the dysregulation of upstream regulatory factors such as SATB2 and NRG1 is involved in the pathogenesis of uterine fibroids. The gene discussed is NRG1; the disease is uterine corpus leiomyoma.