More recently, simulation of routine screening for MODY based on NGS (targeting GCK, HNF1A, HNF4A, ABCC8 and KCNJ11) in all paediatric diabetes, including children with presumed type 1 diabetes, found that this could significantly reduce health system costs and improve patient quality of life in Australia [45]. This evidence concerns the gene HNF4A and diabetes mellitus.