CTNNB1 and hepatocellular carcinoma: We further examined the most consistently dysregulated c3USP, CTNNB1 3′ SP in HCC and found that only over-splicing of the CTNNB1 3′ UTR, but not its somatic mutational status or total transcript expression, was significantly correlated with poorer OS (Fig. 4a), suggesting that its 3′ UTR splicing could be a robust prognosticator for HCC.