These effects were accompanied by a decrease in the protein expression of the respective genes and the repression of tumour growth, likely due to cell cycle inhibition as evident from the downregulated expression of cell cycle genes, including CCNE1, CDK2, CDK4 and CDK6 (Fig. 3g,h and Extended Data Figs. 3e,f and 4a). This evidence concerns the gene CDK4 and neoplasm.