ATP1A1 and neoplasm: Our study further reveals the role of ATP1A1 in heterocellular adhesion and induction of juxtacrine activin A. Therefore, ATP1A1 could be a suitable target for moderately differentiated tumor cells such as BxPC-3 and SU.86.86 cells, which exhibit ATP1A1 overexpression with enhanced mesenchymal properties for metastasis.