RNA sequencing data showed that the primary signaling pathways activated in fibroblasts upon direct contact with ATP1A1-overexpressing tumor cells (BxPC-3 and SU.86.86 cells, but not MIA PaCa-2 and PANC-1 cells) were calcium-dependent axonal guidance and CREB signaling (Fig. 7f). Here, CREB1 is linked to neoplasm.