Consistently, αSMA, collagen I, and collagen contractility were also increased in fibroblasts in direct contact with tumor cells (Fig. 4o, p; Supplementary Fig. 3d), while neutralization with anti-activin A antibody diminished αSMA expression and collagen contractility in fibroblasts (Fig. 4q; Supplementary Fig. 3e). Here, ACTA1 is linked to neoplasm.